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Your Position: ホーム > Fc gamma RIIB / CD32b

Fc gamma RIIB / CD32b

概要

Name:Low affinity immunoglobulin gamma Fc region receptor II-b
Target Synonym:IgG Fc Receptor II-C,Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32),Fc Gamma Receptor IIb,IgG Fc Receptor II-B,Fc-Gamma RII-B,FcRII-B,CDw32,FCG2,Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B,Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32),Fc Gamma RIIb,CD32 Antigen,CD32B,FCGR2,Fc-gamma-RIIb,FCGR2B,IGFR2,CD32,Fc Fragment Of IgG Receptor IIb,Fc-Gamma RII-C,Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C,Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
CDB-R52H3 Rat Rat Fc gamma RIIB / CD32b Protein, His Tag (MALS verified)
CDB-R52H3-structure
CDB-R52H3-sds
SCCHO-ATP060H Human CHO/Human CD32b Stable Cell Line (High Expression) Development Service
SCCHO-ATP060M Human CHO/Human CD32b Stable Cell Line (Medium Expression) Development Service
SCCHO-ATP060L Human CHO/Human CD32b Stable Cell Line (Low Expression) Development Service
CDB-C5224 Cynomolgus Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified)
CDB-C5224-structure
CDB-C5224-sds
CDB-C82E4 Cynomolgus Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDB-C82E4-structure
CDB-C82E4-sds
CDB-M82E8 Mouse Biotinylated Mouse Fc gamma RIIB / CD32b Protein, Avitag™,His Tag (SPR & BLI & MALS verified)
CDB-M82E8-structure
CDB-M82E8-sds
CDB-M52H7 Mouse Mouse Fc gamma RIIB / CD32b Protein, His Tag (SPR & BLI & MALS verified)
CDB-M52H7-structure
CDB-M52H7-sds
ACRO Quality

生物活性データの一部

SCCHO-ATP060H-Cell-based assay
Fc gamma RIIB / CD32b FACS

Expression analysis of human CD32b on CHO/Human CD32b Stable Cell Line by FACS.
Cell surface staining using PE/Cy7-labeled anti-human CD32b antibody was performed on CHO/Human CD32b Stable Cell Line with different expression levels: CHO/Human CD32b Stable Cell Line (Low Expression); CHO/Human CD32b Stable Cell Line (Medium Expression); CHO/Human CD32b Stable Cell Line (High Expression).

Protocol
SCCHO-ATP060M-Cell-based assay
Fc gamma RIIB / CD32b FACS

Expression analysis of human CD32b on CHO/Human CD32b Stable Cell Line by FACS.
Cell surface staining using PE/Cy7-labeled anti-human CD32b antibody was performed on CHO/Human CD32b Stable Cell Line with different expression levels: CHO/Human CD32b Stable Cell Line (Low Expression); CHO/Human CD32b Stable Cell Line (Medium Expression); CHO/Human CD32b Stable Cell Line (High Expression).

Protocol
CDB-R52H3-SPR
Fc gamma RIIB / CD32b SPR

GMP Monoclonal Anti-Human CD3 Antibody (OKT3) (Cat. No. GMP-MC0323) immobilized on CM5 Chip can bind Rat CD32b Protein, His Tag (Cat. No. CDB-R52H3) with an affinity constant of 1.93 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
CDB-C5224-SPR
Human_FcRn_Heterodimer_Protein_SPR

Cynomolgus CD32b, His Tag (Cat. No. CDB-C5224) captured on CM5 chip via anti-His antibody can Herceptin® with an affinity constant of 11.9 μM as determined in a SPR assay (Biacore T200) (QC tested).

Protocol

Synonym Name

FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32

Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
BI-1607 BI-1607 Phase 2 Clinical Bioinvent International Ab Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Metastatic breast cancer; Adenocarcinoma Details
PRV-3279 MGD-010; PRV-3279; CD32BxCD79B Phase 2 Clinical Macrogenics Inc Drug-Related Side Effects and Adverse Reactions Details
BI-1206 6G-11; BI-1206 Phase 2 Clinical Bioinvent International Ab Lymphoma, B-Cell; Solid tumours; Waldenstrom Macroglobulinemia; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details

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